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KMID : 0191120110260060829
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Journal of Korean Medical Science
2011 Volume.26 No. 6 p.829 ~ p.831
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Lineage Switch at Relapse of Childhood Acute Leukemia: A Report of Four Cases
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Park Mee-Rim
Koh Kyung-Nam
Kim Bo-Eun
Im Ho-Joon
Jang Seong-Soo
Park Chan-Jeoung
Chi Hyun-Sook
Seo Jong-JIn
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Abstract
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Lineage switch in acute leukemia is an uncommon event at relapse, and therefore rarely reported in the literature. Here, we have described the clinical laboratory features of four cases in which the cell lineage switched from acute lymphoblastic leukemia (ALL) to acute myeloid leukemia (AML). One patient was initially diagnosed with B-ALL, switched to T-ALL at the first relapse, and eventually, AML at the second relapse. A lineage switch represented either relapse of the original clone with heterogeneity at the morphologic level or emergence of a new leukemic clone. Further sequential phenotypic and cytogenetic studies may yield valuable insights into the mechanisms of leukemic recurrence, with possible implications for treatment selection.
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KEYWORD
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Lineage Switch, Acute Leukemia
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